Neurodegenerative Diseases

From Molecular Concepts to Therapeutic Targets

  • Rommy Bernhardi Nibaldo C. Inestrosa
€ 170,44
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This book discusses in detail the different hypothesis and experimental evidence regarding the neurobiological mechanisms involved in neurodegenerative pathology, with an emphasis in Alzheimer's and Parkinson's disease. Since there are many hypotheses for neurodegenerative diseases, there is a real need for a comprehensive view, allowing for integration of the different views for the pathogenic mechanisms of the disease.
Introduction; Impact of Intracellular Ass amyloid Peptide in Health and Disease; Soluble Ass Oligomers in Alzheimer's Disease; Inhibitory Effects of Ass-amyloid Aggregates on Synaptic Transmission in Hippocampal Neurons; Role of LIMK1 in Neuronal Degeneration in Alzheimer's Disease; Amyloid-Ass-Peptide Activates the Neuronal C-ABL Tyrosine Kinase/ Signaling the Transduction Pathway; Neuroprotection by Astrocytes Involves Multiple Regulatory Mechanisms; Wnt Signaling and its Importance in Alzheimer's Disease; Glycogen Synthase Kinase 3 (GSK-3) As A Molecular Target for Alzheimer's Disease and Other Tauopathies; Inverse Association Between Cancer and Dementia of the Alzheimer's Type; Wnt Signaling in Spinal cord Connectivity; Protein Nitrotyrosination in Alzheimer's Disease; The Ryanodine Receptors / Calcium Release Channels as Neuronal Redox Sensors; Reactive Oxygen Species Signaling in the Hippocampus; Role of Copper in Alzheimer's Disease and other Neuropathological Disorders; Zn2+-protein Interactions in Normal Brain Physiology and Neuropathology; Iron Toxicity; A Critical Review on its Role in Parkinson's Disease; Index.
Uitgavejaar 2008
ISBN 9781604561678
Verschijningsdatum 1 jun. 2008
Omvang 219
Auteur(s) Rommy Bernhardi Nibaldo C. Inestrosa
Bindwijze Gebonden
Taal Engels
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